ReShape Lifesciences® to Present Data on its Proprietary Diabetes Bloc-Stim Neuromodulation™ Device at the Keystone Symposia on Type 2 Diabetes
“Neuromodulation has demonstrated utility for the treatment of multiple diseases, representing a potential, unique treatment option for type 2 diabetes mellitus (T2DM), and we have demonstrated increased glycemic control in Zucker rodent and swine models of T2DM by utilizing sub-diaphragmatic vagus nerve neuromodulation with our DBSN™ device,” stated
Poster Details:
- Poster Title: Targeted Dual Sub-Diaphragmatic Vagus Nerve Neuromodulation Increased Performance on Oral Glucose Tolerance Tests and Reversed Fasting Plasma Glucose from Pre-Diabetic to Non-Diabetic Levels in Alloxan Treated Swine with Mild Glucose Intolerance
- Poster Number: 2004
- Authors: Jonathan J Waataja,
ReShape Lifesciences Inc. ;Maneesh Shrivastav ,Medtronic, Inc. ; Charles J Billington,Veterans' Administration Medical Center ,Minneapolis, MN - Session: Poster Session 2
- Date:
Wednesday, May 3, 2023 - Time:
7:30 pm PT
Increased glycemic control was demonstrated in a Zucker rodent model of T2DM by utilizing sub-diaphragmatic vagus nerve dual neuromodulation, utilizing reversible high frequency alternating current (at 5000 Hz) induced conduction block of the hepatic branch of the vagus nerve (innervating the liver), with simultaneous stimulation of the celiac branch of the vagus nerve (innervating the pancreas). The dual neuromodulation was found to be superior to standalone block or stimulation. These results were replicated in a chronic study in glucose intolerant alloxan treated swine. In both experiments, the animals demonstrated high fasting plasma glucose (FPG) and significant glucose intolerance, characteristics of an overt diabetic state. Subsequently, dual neuromodulation was tested on swine that had attributes consistent of pre- and early-stage diabetes, including non-alloxan and alloxan treated with mild glucose intolerance. Dual neuromodulation increased glycemic control in both groups which was demonstrated by increased performance on oral glucose tolerance tests (OGTTs) and also induced long lasting decreases in FPG. Following applications of block and stimulation (two days of separation), FPG decreased from an average of 102±8 mg/dL (considered prediabetic) to 74±2 mg/dL (considered non-diabetic).
“The compelling data on our proprietary DBSN™ device, presented at the Keystone Symposia on Type 2 Diabetes, further validates the market potential of this technology,” stated
About Diabetes Bloc-Stim Neuromodulation™ Device
The Diabetes Bloc-Stim Neuromodulation™ (DBSN™) system is a novel therapeutic concept that is implanted minimally invasively and delivers bio-electronic neuromodulation of vagus nerve branches that are innervating organs which regulate plasma glucose. The DBSN™ system stimulates vagus celiac fibers of the pancreas to release insulin during stimulation, while electrically blocking the hepatic vagal branch, innervating the liver, to decrease glucose release and decrease insulin resistance following nerve blockade. The DBSN™ system utilizes a proprietary, reversable and adjustable electrical blockade felt to be key to the future of personalized medicine. The DBSN™ system is superior to both standalone stimulation of the vagus nerve that has shown mixed results, and vagus nerve ligation that has undesirable effects.
About ReShape Lifesciences™
Forward-Looking Safe Harbor Statement
This press release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Actual results could differ materially from those discussed due to known and unknown risks, uncertainties, and other factors. These forward-looking statements generally can be identified by the use of words such as "expect," "plan," "anticipate," "could," "may," "intend," "will," "continue," "future," other words of similar meaning and the use of future dates. Forward-looking statements in this press release include statements about our the DBSN™ system’s potential treatment of T2DM. These and additional risks and uncertainties are described more fully in the company's filings with the
CONTACTS
ReShape Lifesciences Investor Contact:
Chief Financial Officer
949-276-6042
ir@ReShapeLifesci.com
Investor Relations Contact:
(917)-633-6086
mmiller@rxir.com

Source: ReShape Lifesciences Inc