ReShape Lifesciences® Presents Data on its Proprietary Diabetes Bloc-Stim Neuromodulation™ Device at the ASMBS 2023 Annual Meeting
“Type 2 Diabetes Mellitus (T2DM) remains challenging to effectively treat, despite medication, surgery and diet,” stated
- Poster Title: The Insulin Response to Oral Glucose Tolerance Tests did not Diminish Following Prolonged Stimulation of the Vagus Nerve Celiac Branch in the Study of a Novel Bioelectronic Treatment for Type 2 Diabetes Mellitus
- Poster Number: A223
Jonathan J. Waataja, Ph.D.
- Session: E-Posters
June 27, 2023
9:00 am -12:30 pm PT
In swine experiments (n=3) glycemic control was assessed by applying stimulation and block for the duration of six 4-hour oral glucose tolerance tests (OGTTs). The total cumulative time was 24 hours which may lead to beta cell exhaustion. To test for exhaustion blood insulin was measured during an OGTT prior to and following experiments. The insulin response was quantified by calculating the area under the curve (AUC) of insulin versus time (µIU/mL*min=area unit (AU)). There was an apparent, but non-significant, increase in baseline insulin following stimulation and block experiments (pre-experiments =10.7±2.6 µIU/mL, post-experiments=15.4±2.9 µIU/mL, p=0.28). In terms of overall response there was no significant change in AUC (pre-experiments =3906±565 AU, post-experiments=5866±698 AU, p=0.09).
“The presentation of this data at such an important industry conference is a testament to the strength of the pre-clinical evidence showing our proprietary DBSN™ device’s potential to address the enormous T2DM market,” stated
About Diabetes Bloc-Stim Neuromodulation™ Device
The Diabetes Bloc-Stim Neuromodulation™ (DBSN™) system is a novel therapeutic concept that is implanted minimally invasively and delivers bio-electronic neuromodulation of vagus nerve branches that are innervating organs which regulate plasma glucose. The DBSN™ system stimulates vagus celiac fibers of the pancreas to release insulin during stimulation, while blocking the hepatic vagal branch, innervating the liver, to decrease glucose release and decrease insulin resistance following ligation. The DBSN™ system utilizes a proprietary, reversable and adjustable electrical blockade felt to be key to the future of personalized medicine. The DBSN™ system is superior to both standalone stimulation of the vagus nerve that has shown mixed results, and vagus nerve ligation that has undesirable effects.
About ReShape Lifesciences™
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This press release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Actual results could differ materially from those discussed due to known and unknown risks, uncertainties, and other factors. These forward-looking statements generally can be identified by the use of words such as "expect," "plan," "anticipate," "could," "may," "intend," "will," "continue," "future," other words of similar meaning and the use of future dates. Forward-looking statements in this press release include statements that the DBSN™ device, with further studies, may hold significant promise to treat T2DM and our efforts to potentially bring this novel therapeutic to market . These and additional risks and uncertainties are described more fully in the company's filings with the
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